The Fueling Evidence File

Angela Naeth Coaching · ANC Performance System™

The Fueling Evidence File

The peer-reviewed foundation behind every recommendation in the ANC Race & Training Fueling Library.

Part of the ANC Race & Training Fueling Library
Chapter 01

Why This File Exists

The endurance nutrition space is loud, opinionated, and full of advice that contradicts itself month to month. This file exists for one reason: every recommendation in the ANC Race & Training Fueling Library can be traced to peer-reviewed research, an IOC or ACSM consensus statement, or a well-replicated clinical or field study.

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Chapter 02

How to Read This File

Each topic chapter is structured the same way: The Claim, The Evidence, The Caveats, and The Application — pointing back to the specific playbooks where each finding is applied.

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Chapter 03

Carb Loading & Supercompensation

The Claim: A 36–48 hour high-carb intervention (9–12 g/kg/day) combined with reduced training volume produces glycogen supercompensation in trained athletes, improving performance in events >90 minutes. The depletion phase of the classical protocol is unnecessary.

01 Bergström, J., et al. (1967). Diet, muscle glycogen and physical performance. Acta Physiologica Scandinavica.
Takeaway: Original demonstration that high-carbohydrate intake elevates muscle glycogen above baseline and extends time-to-exhaustion.
02 Sherman, W. M., et al. (1981). Effect of exercise-diet manipulation on muscle glycogen and its subsequent utilization during performance. International Journal of Sports Medicine.
Takeaway: Modified carb-loading protocol without a depletion phase produced glycogen levels equal to the classical Scandinavian protocol.
03 Burke, L. M., et al. (2011). Carbohydrates for training and competition. Journal of Sports Sciences.
Takeaway: Consensus review establishing g/kg/day targets including 10–12 g/kg/day for pre-race loading in events >90 min.

Applied in

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Chapter 04

Race-Day Carbohydrate Intake

The Claim: In-race carbohydrate intake of 60–120 g/hr improves performance in endurance events >90 minutes. Recent evidence supports the upper end (90–120 g/hr) in gut-trained athletes for events >3 hours.

05 Jeukendrup, A. E. (2014). A step towards personalized sports nutrition: carbohydrate intake during exercise. Sports Medicine.
Takeaway: Definitive review establishing the g/hr framework and dual-transporter biology.
07 Sampson, G., et al. (2024). Carbohydrate ingestion of 120 g/h reduces oxygen cost during marathon running compared with 60 g/h. Medicine & Science in Sports & Exercise.
Takeaway: Elite marathoners showed measurably lower oxygen cost at 120 g/hr vs 60 g/hr.

Applied in

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Chapter 05

Dual Transporters & the 60 g/hr Wall

The Claim: Single-transporter carbohydrate products saturate at approximately 60 g/hr. Co-ingestion of fructose allows absorption up to 90–120 g/hr.

09 Jentjens, R. L., et al. (2004). High oxidation rates from combined carbohydrates ingested during exercise. Medicine & Science in Sports & Exercise.
Takeaway: Glucose + fructose blends produced 36% higher exogenous carbohydrate oxidation than glucose alone.

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Chapter 06

Gut Physiology & Run-vs-Bike

The Claim: Running mechanically and physiologically reduces gut tolerance for carbohydrate compared to cycling. Run g/hr targets should be set at approximately 78–85% of bike g/hr targets.

12 Costa, R. J. S., et al. (2017). Systematic review: exercise-induced gastrointestinal syndrome. Alimentary Pharmacology & Therapeutics.
Takeaway: Mechanically-driven gut permeability changes are greater in running than cycling.

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Chapter 07

Hydration & Hyponatremia

The Claim: In-race fluid intake of approximately 75% of sweat-rate losses, paired with sodium intake calibrated to individual sweat sodium loss, optimizes performance and minimizes hyponatremia risk.

16 Hew-Butler, T., et al. (2015). Statement of the Third International Exercise-Associated Hyponatremia Consensus Development Conference. Clinical Journal of Sport Medicine.
Takeaway: Over-drinking — not under-drinking — is the dominant cause of exercise-associated hyponatremia.

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Chapter 08

Caffeine

The Claim: Caffeine at 1–3 mg/kg body weight improves endurance performance by 3–6% through reduced perceived exertion and increased central drive.

20 Maughan, R. J., et al. (2018). IOC consensus statement: dietary supplements and the high-performance athlete. British Journal of Sports Medicine.
Takeaway: IOC identifies caffeine as one of a small number of supplements with strong evidence for performance benefit in endurance sport.

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Chapter 09

Carb Mouth Rinse

The Claim: Swishing a 6% carbohydrate solution for 5–10 seconds without swallowing improves performance by 2–3% in events under 60 minutes via central nervous system mechanisms.

21 Carter, J. M., et al. (2004). The effect of carbohydrate mouth rinse on 1-h cycle time trial performance. Medicine & Science in Sports & Exercise.
Takeaway: 2.9% performance improvement from carb mouth rinse alone — without ingesting any carbohydrate.
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Chapter 10

Recovery & the Post-Exercise Window

The Claim: Consuming 1.0–1.2 g/kg carbohydrate plus 20–40 g protein within 30 minutes of finishing a hard or long session maximizes glycogen resynthesis and muscle protein synthesis.

23 Beelen, M., et al. (2010). Nutritional strategies to promote postexercise recovery. International Journal of Sport Nutrition and Exercise Metabolism.
Takeaway: Establishes the 30-minute carb + protein window and the 1.0–1.2 g/kg carbohydrate target for rapid glycogen restoration.

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Chapter 11

Female Athletes, Iron & RED-S

The Claim: Female endurance athletes have distinct physiological considerations: cycle-phase variations in thermoregulation and substrate use, elevated iron deficiency risk, and significant RED-S prevalence.

26 Mountjoy, M., et al. (2018). IOC consensus statement on Relative Energy Deficiency in Sport (RED-S): 2018 update. British Journal of Sports Medicine.
Takeaway: IOC consensus defining RED-S, its health and performance consequences, and the central role of adequate energy availability.

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Chapter 12

Gut Training as a Skill

The Claim: The gut is a trainable organ. Progressive exposure to high carbohydrate intake during exercise — over 4–12 weeks — increases tolerance and absorption capacity.

30 Jeukendrup, A. E. (2017). Training the gut for athletes. Sports Medicine.
Takeaway: Gut training is a deliberate adaptation including increased gastric emptying capacity and upregulated SGLT1 and GLUT5 transporter expression.

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Chapter 13

How This Evidence Shows Up in the Playbooks

Every playbook in the library draws on the citations in this file.

The Standing Invitation

If you are a coach, journalist, registered dietitian, or sports physician and you want to verify, challenge, or discuss any claim in the library — reach out. The science is the foundation; the playbooks are the application. Both should withstand scrutiny.

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Science You Can Race On

The library you've just read is built on this foundation. The plan you build for race day deserves the same rigor.

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